FT-Raman studies on the hydrocarbon chain sturcture of sphingomyel-in vesicles containing GM1 ganglioside and cholesterol

摘要

The hydrocarbon chain structure of sphingomyelin(SM) vesicles containing GM1 ganglioside and cholesterol has been investigated by FT-Raman. It has been reported that membrane fractions prepared by the different techniques are peculiarly enriched in glycolipids, cholesterol, and sphingomyelin, and depleted of phosphatidylcholine[1]. Such lipid domains are postulated to function as platforms involved in the lateral sorting of certain proteins during their trafficking within cells as well as during signal transduction events.