Spectroscopic Study of Magnesium Effect on Stability of RNA and DNA Triple Strand Polynucleotide

摘要

Double-stranded helix is the most frequent secondary structure adopted by nucleic acids. In its native state DNA is almost exclusively double stranded, while short segments of internal duplexes stabilize various motifs of RNA secondary structure. In general, duplex nucleic acids are able to adopt different conformations: DNA is usually found under physiological conditions as B-DNA while RNA duplexes and DNA–RNA hybrids commonly adopt an A-type conformation.