Efficacy of florfenicol administered in drinking water in the treatment of naturally occurring swine respiratory disease

摘要

Objective: To evaluate the efficacy of florfenicol administered in drinking water for three or five days at 200 or 400 mg/gallon for treatment of naturally occurring swine respiratory disease. Animals: 244 pigs with a mean body weight of 27.4 kg. Procedure: Two studies were conducted with pigs from herds in Nebraska and Ohio with histories of Actinobacillus pleuropneumoniae (APP) pleuropneumonia. Pigs with pyrexia (>=104.5 deg F or 40.3(C) were allotted to five groups and offered either nonmedicated drinking water or water medicated with florfenicol at 200 or 400 mg/gallon for three or five days. Pigs were clinically examined daily until two days post-medication. Treatment success was determined at two days post-medication and from study days 7 through 11, after which all pigs were necropsied. Results: The daily mean rectal temperatures of all florfenicoltreated groups were statistically significantly lower (p<0.05) than those of nonmedicated pigs from study days 2 through 5. The mean lung consolidation percentages for the 400x5, 200x5 and 400x3 groups were significantly lower than those of the 200x3 and nonmedicated groups. On Day 7, the success rate of the 400x5 group was significantly higher than that of all other groups. Transient, mild or moderate perianal inflammation occurred in all florfenicol groups. The MIC_(90) of florfenicol to APP (n=94) recovered from culture of nasal swabs or lung tissue was 0.5 #mu#g/mL. Conclusion: Florfenicol administered in drinking water was effective in the treatment of swine respiratory disease. The optimal dosage rate was 400 mg/gallon for five days.