A field study of the efficacy of an Actinobacillus pleuropneumoniae subunit vaccine in the control of pleuropneumonia caused by Actinobacillus pleuropneumoniae serotype 6

摘要

Actinobacillus pleuropneumoniae (App), the causative agent of porcine pleuropneumonia, is very common in fattening pigs in Norway, and serotypes 2, 6, 7, 8 and 10 seems to be the most frequent. Although the App infection is subclinical in most herds,it may in some herds be responsible for major economic losses due to acute or chronic pleuropneumonia, reduced daily weight gain and increased carcass condemnation. In some herds, chronic pleuritis is found in 80 - 90 percent of the slaughtered pigs. During the last few years both challenge experiments and field trials have shown that an App subunit vaccine containing Apxl, ApxII, ApxIII and outer membrane protein (OMP) antigens produced by strains of App, is protective against lung lesions caused by infections with different serotypes of App. The present study was performed to investigate the efficacy and safety of a commercial subunit vaccine against App infection when used in a naturally infected farrow to finish herd.