Removal pathway of silicon released from bioactive glass granules in vivo

摘要

In this study we traced and quantified the silicon released from bioactive glass granules (BGG) in vivo (45S5, 300-355 mu m). 1500 mg of BGG were implanted in the paraspinal muscle of 4 kg rabbits. Blood and urine samples were obtained weekly. After 6 weeks, the rabbits were euthanized and the following tissues and organs were harvested: local muscle, appendix, brain, heart, kidney, liver, lung, and thymus. Using flame atomic absorption spectrophotometry, the concentration of elemental silicon (Si) was measured in these fluid, tissues, and organs.