Comparison of the optical properties of human liver tissue and liver metastases and investigation of the dynamic temperature behavior of optical tissue properties

摘要

The knowledge of the optical properties of human tissue is indispensable for the understanding and optimal use of laser applications in medicine, especially for dosimetrical questions in laser-induced thermotherapy of liver metastases. In addition photothermal therapies have to consider the dynamic behavior of optical properties. In this study we evaluated the optical tissue properties of normal human liver tissue and of colorectal liver metastases. We used the double integrating sphere technique and the inverse Mont Carlo- simulation for evaluation of the optical properties. We were able to demonstrate significant differences between native and coagulated tissue as well as between normal and metastatic tissue. In the investigation of the dynamic temperature behavior of optical properties we could demonstrate that the coagulation rate cannot be described by a linear model.