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Dynamic free-boundary model for laser thermal tissue coagulation

机译:激光热组织凝固动态自由边界模型

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In the previous paper we have proposed a new mathematical model for local thermal coagulation due to laser light absorption and the corresponding necrosis growth. The classic bioheat equation does not hold on small spacial scales on which the fraction of undamaged tissue varies substantially. Therefore we use the free boundary approach regarding the region of partially damaged tissue as an infinitely thin layer. In order to complete the free boundary approach certain conditions should be imposed on the temperature distribution at this interface. Previously we have assumed that the coagulation occurs when the temperature at the necrosis interface exceeds a certain threshold value. This approximation, however can lead to a wrong prediction for treatment of long duration. In the present work we generalize this model which no longer considers the interface temperature fixed and is based on the relation between the interface velocity and the boundary values of temperature distribution. It is shown that this model describes adequately the necrosis growth also in the treatment course of long duration.
机译:在前一篇论文中,我们提出了一种用于局部热凝固的新数学模型,由于激光吸收和相应的坏死生长。经典的生物发热方程没有保持在少的空间尺度上,其中未损坏的组织的分数大幅不同。因此,我们使用关于绝部受损组织区域作为无限薄层的区域的自由边界方法。为了完成自由边界方法,应对该界面的温度分布施加某些条件。以前我们假设在坏死界面的温度超过某个阈值时发生凝血。然而,这种近似可能导致对持续时间的治疗错误的预测。在本工作中,我们概括了该模型,该模型不再认为接口温度固定,并且基于接口速度与温度分布边界值之间的关系。结果表明,该模型在长期持续时间的治疗过程中也适当地描述了坏死的增长。

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