New chlorin and bacteriochlorine-type photosensitizers for photodynamic therapy

摘要

New chlorins and bacteriochlorins as perspective sensitizers for photodynamic therapy were synthesized. The influence on the position and the character of the substituents on the sensitizer optical properties was studied. The series of water soluble chlorin p$-6$/ derivatives with graded amphiphility were synthesized for studies on tumor accumulation. The influence of pH on sensitizer amphiphility was discussed. The photostability of water soluble chlorins and bacteriochlorins has been examined.