For the first time in science, near infrared spectral data of bodyfluid, milk, have been used for non-invasive disease diagnosis(mammary gland inflammation) in dairy cows1 in 1985, in acollaborative study done in Bulgaria and Russia. Later on, in2013, in-vivo diagnosis of the same disease has been achievedat Kobe University in Japan using the spectra of mammarygland tissue2 acquired by Fantec NIR instrument in the rangeof 600– 1100nm. Our Laboratory of Bio measurementTechnology at Kobe University, Japan has been the leader inthis field using Near infrared spectra for diagnosis of manyother diseases like prion disease in mouse, mosaic virus insoybean, HIV in humans, oxidative stress etc., for pathogenidentification and other physiological studies like diagnosis ofestrus in animals, real time amyloid genic nucleationmonitoring, UV-induced DNA cyclobutane pyrimidine dimersetc. In 1996, thanks to the Japanese scientific grant for 5 years,5 teams (Japanese National Institutes of Animal Welfare andFood Science and 3 universities: Hokkaido University,Kwansei University and Kobe University, have been workingon NIR spectroscopy for Bio measurements3. One of the mainachievements was the discovery that the mammary glandinflammation can be diagnosed not only by the spectra of milkor udder tissue. Similar accuracy has been achieved whenusing other respective bio fluids like blood or urine spectra.High correlation has been observed between the componentsof one bio fluid and the spectra of other bio fluid, too. The maindifference in the spectra of healthy and diseased animals hasbeen found in the spectral pattern of water in the bio fluids ortissue. These findings lead to the discovery that a vastinformation is hidden in the long time neglected and avoidedwater absorbance regions in the NIR spectra.
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