Flexible neural probes with micro-fluidic channels for stable interface with the nervous system

摘要

A flexible neural probe with micro-fluidic channels has been developed. The probe is sufficiently flexible to enable minimally invasive recording. The fluidic channel integrated on the probe is capable of injecting chemicals into neural tissues. In addition, it permits a stable interface with the nervous system. We focus on issues concerning: 1) stable recording with electrodes placed in fluidic channels, 2) improved mechanical stiffness by filling channels with a solid that dissolves in neural tissues, and 3) the probe's application to a nerve regeneration electrode.