Dental Amalgams and Risk of Gestational Hypertension in the MIREC Study

摘要

Background: The potential association between the presence or replacement of dental amalgams and gestational hypertension with or without preeclampsia (GH) is unclear. Objective: To assess the association between the presence or replacement of dental amalgams and the risk of GH in a prospective cohort study. Methods: We assessed dental amalgam status (presence or replacement), blood mercury concentrations, and measured blood pressure in 1909 pregnant women recruited in 10 Canadian cities between 2008 and 2011 as part of the Maternal-Infant Research on Environmental Chemicals (MIREC) Study. Blood pressure was assessed in each trimester of pregnancy and mercury concentrations in 1st and 3rd trimesters. Logistic regression analysis was performed to estimate the adjusted odds ratio (aOR) and 95% confidence intervals (CI) for the association between dental amalgam status and GH. Concurrent measures with GH were assessing through logistic generalized estimating equations. Results: Dental amalgam status was weakly and statistically correlated with blood mercury concentrations but there was no evidence of an association with GH in women having 1-4 (aOR = 1.31; 95% CI: 0.92,1.85) or > 5 dental amalgams (aOR = 1.32; 95% CI: 0.86, 2.04), compared to women without amalgam reported at first trimester. Dental amalgam replacement reported in the first or third trimester was similarly not associated with GH (aOR = 0.75; 95% CI: 0.40, 1.42 and aOR = 0.73; 95% CI: 0.39, 1.34, respectively). Conclusion: We found weak correlations between dental amalgams and blood mercury among pregnant women. However, the presence of dental amalgams or their replacement was not associated with a statistically significant increase in GH risk. Further studies are required to confirm these results.