Consensus gene modules identification of cervical cancer and head neck cancer

摘要

Objectives: Squamous cell carcinoma (SCC) is the most common histological type of head neck cancer and cervical cancer. Carcinogenesis in these two types of cancers demonstrate similar multistep progression. The purpose of the study is to identify the significant consensus gene modules of these two cancers. Materials and Methods: We used a publicly available expression dataset for the study. The dataset included head neck cancer (42 cancer samples and 14 normal samples) and cervical cancer (20 cancer samples and 8 normal samples). We used only human papilloma virus 16 positive samples for excluding the bias according to the different types of HPV. We identified consensus modules of two types of cancers and explored the biological functions of each modules by annotation tool. Results: We identified 8 consensus gene modules of head neck cancer and cervical cancer. Each module was well preserved between the two types of cancer. The modules included significant biological functions, including ATP binding and extracellular exosome. Conclusion: Consensus gene module identification is expected to contribute to more personalized management of multiple cancer types. The identified consensus modules could be common targets for multicancer therapy.