Centrality in Epidemic Networks with Time-Delay: A Decision-Support Framework for Epidemic Containment

摘要

During an epidemic, infectious individuals might not be detectable until some time after becoming infected. The studies show that carriers with mild or no symptoms are the main contributors to the transmission of a virus within the population. The average time it takes to develop the symptoms causes a delay in the spread dynamics of the disease. When considering the influence of delay on the disease propagation in epidemic networks, depending on the value of the time-delay and the network topology, the peak of epidemic could be considerably different in time, duration, and intensity. Motivated by the recent worldwide outbreak of the COVID-19 virus and the topological extent in which this virus has spread over the course of a few months, this study aims to highlight the effect of time-delay in the progress of such infectious diseases in the meta-population networks rather than individuals or a single population. In this regard, the notions of epidemic network centrality in terms of the underlying interaction graph of the network, structure of the uncertainties, and symptom development duration are investigated to establish a centrality-based analysis of the disease evolution. A traffic volume convex optimization method is then developed to control the outbreak by identifying the sub-populations with the highest centrality and then isolating them while maintaining the same overall traffic volume (motivated by economic considerations) in the meta-population level. The numerical results, along with the theoretical expectations, highlight the impact of time-delay as well as the importance of considering the worst-case scenarios in investigating the most effective methods of epidemic containment.