In vivo dual-mode full-field optical coherence tomography for differentiation of different types of melanocytic nevus

摘要

Mirau-type full-filed optical coherent tomography (FF-OCT) can provide imaging with cellular resolution section of human skin in vivo. In our previous work, the concept of dual-mode FF-OCT for cross-sectional (B-scan) and en face (E-scan) imaging with symmetrical illumination has been reported. This work presents a prototype of the dual-mode FF-OCT system and demonstrates the improvement of the efficiency for clinical applications. For clinical diagnosis, it is helpful to differentiate different types of nevus. Thus, an imaging tool capable of identifying the types of nevus is crucial. Our system can switch between two modes of imaging automatically by just clicking a button. The feature allows clinicians to explore the nevus more efficiently. While the B-scan images reveal the distribution of melanosomes, users can set a specific depth of the E-scan images to explore the morphology of surrounding skin cells instantly. The different types of nevus including junction nevus, intradermal nevus and compound nevus can be identified by using this dual-mode FF-OCT system.