Nanodelivery of Chinese traditional medicine extract of Gingko Biloba (EGb-761) induces superior neuroprotection following traumatic brain injury in heat stroke

摘要

Heat stroke (HS) affects millions of people worldwide especially during summer months. Military personnel working in hot environment are often highly vulnerable to HS. Morepver when these military personnel during combat operation are inflicted with traumatic brain injury (TBI)at hot envireonment, the pathophysiology of brain dmage is far more serious than the identical brain trauma at thermoneutral ambient temperature. Thus, efforts are needed to find out superior neuroprotective therapy in situations of TBI at hot environment. The traditional Chinese mediicne extract of Gingko Biloba (EGb-761) is used for mental health and other disease as antioxidant. Previosuly we reported marked neuroproetction following heat exposure induced brain pathology by EGb-761. Thus, apossibility exists that nanodelivery of EGb-761 may have additional suprior neuroproetctive effects on TBI induced brainpathology at hot environment. Our results showed that Ti02-nanowired delivery of EGb-761 (50 mg/kg,p.o.) or BN-52021 (2 mg/kg, p.o.) for 5 days induced significant neuroprotection following TBI in HS, not reported earlier.