Clinical Intererest of High Frequency Transient Elastography to Assess Dermis Fibrosis in Patients with Venous Insufficiency

摘要

Transient elastography (TE) is a technique used to quantify Young's Modulus (E) by estimating shear wave velocity in homogenous tissues. This technique has been successfully integrated in the Fibroscan^{® device to assess fibrosis stages in liver but has never been validated in the monitoring of skin fibrosis diseases. A specific device based on high-frequency transient elastography (HF-TE) is used to evaluate its performance in case of chronic venous disorder (CVD) diagnosis. E, dermis thickness (DT) and a new parameter, P_E-_DT, based on a logistic regression model using both E and DT are measured in the dermis of 48 healthy and 48 CVD patients. The discriminant capacity of E, DT and Pe-dt parameters is evaluated with a receiver operating characteristic (ROC) analysis.}