Real-time investigation of irreversible cell membrane damage induced by acoustic droplet vaporization

摘要

Acoustic droplet vaporization (ADV) has shown a great potential in extravascular tumor-targeting theranostics. During ADV, its mechanical effects on the nearby cells could cause cell dysfunction with irreversible cell membrane damage or facilitate drug delivery by sonoporation. Understanding the real-time characteristics and bio-effects of ADV on cells is significant to develop the approach in vivo and then in clinic.