Immune Response Enhancement Strategy via Hybrid Control Perspective

摘要

We investigate a control method for disease dynamics, such as HIV and malaria, to boost the immune response using a model-based approach. In particular we apply the control method to select the appropriate immune response between Th1 and Th2 responses. The idea of state jump is introduced and discussed based on hybrid control systems. To implement the control idea we propose physically available methods for each biological system. The studies on malaria model and HIV model are supported by experimental data.