NOVEL IMMUNE STRATEGY AND IMMUNE COMPOSITION FOR ENHANCING ANTI-TUMOUR IMMUNE RESPONSE

摘要

Provided are a novel immune strategy and an immune composition for enhancing the anti-tumour immune response. In particular, the method of the present invention comprises the steps of: (a) providing a first tumour antigen and a second tumour antigen, wherein the enhanced tumour immune response is the enhanced tumour immune response against the first tumour antigen; the first tumour antigen has a low immunogenicity; and the second tumour antigen is a polypeptide that is homologous to and crossed with the first tumour immune antigen or an immunogenic fragment thereof; (b) immunising and administering the second tumour antigen to the mammalian subject, and stimulating an immune response against the second tumour antigen; and (c) immunising and administering the first tumour antigen to the mammalian subject that has undergone the primary immune challenge, and thereby producing an enhanced tumour immune response against the first tumour antigen. Also provided are an immune composition for use in the method of the present invention and the use thereof.