Comparative Analysis on Modularization of Metabolic Network of Methanogens Based on Simulated Annealing Algorithm

摘要

Methanogenic archaea probably played a major role in the evolution of earth's atmosphere. Here we report the results of a comparative analysis of metabolic networks of mesophilic archaeon Methanosarcina acetivorans (M. acetivorans) and the thermophilic archaeon Methanopyrus kandleri (M. kandleri). In this study, we used simulated annealing (SA) to obtain different modules of their metabolic networks. There are 33 and 32 difference modules in M. acetivorans and M. kandleri metabolic networks by SA algorithm. By comparing hub modules, we found conserved functional modules in their metabolic networks are nucleotide metabolism, amino acid metabolism, and carbohydrate metabolism. As has been reported high-degree enzymes turn out to be generally more essential than low-degree enzymes (between metabolic hubs) in several organisms. These results can be used to help guide additional experiments to further the state of knowledge about methanogenesis.