Effect of Curcumin on Biological Behavior of T24 Cells of Bladder Cancer and its Mechanism

摘要

The paper aims at a study of the effect of curcumin on the biological behavior of T24 cells of bladder cancer and its mechanism. After a treatment of T24 cells of bladder cancer with curcumin of different concentration for 24, 48 and 72 h, MTT method is used to examine cell proliferation inhibiting rate, FCM method is used to examine Apoptosis rate, and western blot method is used to examine the NF-KB expression after a treatment of 24 h. Curcumin can inhibit the proliferation of T24 cells and induce its apoptosis. This inhibiting effect bears dependence relation with time and dosage; examination result with western blot method shows that NF-KB expression level lowers with the increase of curcumin treatment concentration, and differences among groups are of statistical significance (P < 0.05). Curcumin can inhibit the proliferation of T24 cells of human bladder cancer and induce its apoptosis, which might be related to the lowering of NF-KB expression level.