Estimation of size distribution for cavitation bubbles combining time intensity curve and bubble dissolution kinetics in tissue

摘要

It has been known that cavitation is the primary mechanism to accelerate ultrasound induced thermal ablation and lesion formation. In order to increase the treatment efficiency, it is useful to know the size of existing cavitation bubbles so as to maximum the bubble oscillation using a frequency corresponds to the bubble resonant frequency at a lower acoustic pressure. In our previous work, a cavitation bubble size estimation method using the time intensity curve and bubble dissolution kinetics in liquid has been developed. In this work, we develop a method to investigate the cavitation bubble size distribution in different sorts of tissue using the bubble dissolution equation in tissue and the time intensity curve for dissolution.