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3D-printed surface mould applicator for high-dose-rate brachytherapy

机译:用于高剂量速率近距离放射治疗的3D印刷表面模具涂抹器

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PURPOSE: In contemporary high-dose-rate brachytherapy treatment of superficial tumors, catheters are placed in a wax mould. The creation of current wax models is a difficult and time consuming proces.The irradiation plan can only be computed post-construction and requires a second CT scan. In case no satisfactory dose plan can be created, the mould is discarded and the process is repeated. The objective of this work was to develop an automated method to replace suboptimal wax moulding. METHODS: We developed a method to design and manufacture moulds that guarantee to yield satisfactory dosimetry. A 3D-printed mould with channels for the catheters designed from the patient's CT and mounted on a patient-specific thermoplastic mesh mask. The mould planner was implemented as an open-source module in the 3D Slicer platform. RESULTS: Series of test moulds were created to accommodate standard brachytherapy catheters of 1.70mm diameter. A calibration object was used to conclude that tunnels with a diameter of 2.25mm, minimum 12mm radius of curvature, and 1.0mm open channel gave the best fit for this printer/catheter combination. Moulds were created from the CT scan of thermoplastic mesh masks of actual patients. The patient-specific moulds have been visually verified to fit on the thermoplastic meshes. CONCLUSION: The masks were visually shown to fit onto the thermoplastic meshes, next the resulting dosimetry will have to be compared with treatment plans and dosimetry achieved with conventional wax moulds in order to validate our 3D printed moulds.
机译:目的:在现代高剂量速率的浅层放射治疗浅表肿瘤的处理中,导管置于蜡型中。当前蜡模型的创建是难以耗时的过程。辐照计划只能计算后施工,需要第二个CT扫描。如果不能产生令人满意的剂量计划,则丢弃模具并重复该过程。这项工作的目的是开发一种替代次优蜡成型的自动化方法。方法:我们开发了一种设计和制造模具的方法,可以保证产生令人满意的剂量测定法。具有由患者CT设计的导管通道的3D印刷模具,并安装在特定患者的热塑网上掩模上。模具策划器在3D Slicer平台中实现为开源模块。结果:采用系列试验模具,以适应直径1.70mm的标准近距离放射治疗导管。校准对象用于得出直径为2.25mm,最小12mm曲率半径的隧道,1.0mm开放通道给出了该打印机/导管组合的最佳拟合。从实际患者的热塑性网状面罩的CT扫描中产生模具。目视验证患者特异性模具以适合热塑性网。结论:视觉上显示掩模以适合热塑性网状物,接下来将得到的剂量测定法与常规蜡模具的治疗计划和剂量法进行比较,以验证我们的3D印刷模具。

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