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3D-printed surface mould applicator for high-dose-rate brachytherapy

机译:用于高剂量率近距离放射治疗的3D打印表面模具施加器

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PURPOSE: In contemporary high-dose-rate brachytherapy treatment of superficial tumors, catheters are placed in a wax mould. The creation of current wax models is a difficult and time consuming proces.The irradiation plan can only be computed post-construction and requires a second CT scan. In case no satisfactory dose plan can be created, the mould is discarded and the process is repeated. The objective of this work was to develop an automated method to replace suboptimal wax moulding. METHODS: We developed a method to design and manufacture moulds that guarantee to yield satisfactory dosimetry. A 3D-printed mould with channels for the catheters designed from the patient's CT and mounted on a patient-specific thermoplastic mesh mask. The mould planner was implemented as an open-source module in the 3D Slicer platform. RESULTS: Series of test moulds were created to accommodate standard brachytherapy catheters of 1.70mm diameter. A calibration object was used to conclude that tunnels with a diameter of 2.25mm, minimum 12mm radius of curvature, and 1.0mm open channel gave the best fit for this printer/catheter combination. Moulds were created from the CT scan of thermoplastic mesh masks of actual patients. The patient-specific moulds have been visually verified to fit on the thermoplastic meshes. CONCLUSION: The masks were visually shown to fit onto the thermoplastic meshes, next the resulting dosimetry will have to be compared with treatment plans and dosimetry achieved with conventional wax moulds in order to validate our 3D printed moulds.
机译:目的:在当代高剂量近距离放射治疗浅表性肿瘤中,将导管放置在蜡模中。当前蜡模型的创建是一个困难且耗时的过程。辐照计划只能在施工后进行计算,并且需要进行第二次CT扫描。如果无法创建令人满意的剂量计划,则将模具丢弃并重复该过程。这项工作的目的是开发一种自动方法来替代次优的蜡模。方法:我们开发了一种设计和制造模具的方法,以确保产生令人满意的剂量学。 3D打印的模具,带有用于从患者CT设计的导管通道,并安装在患者专用的热塑性网状面罩上。模具计划器在3D Slicer平台中作为开源模块实现。结果:创建了一系列测试模具,以容纳直径为1.70mm的标准近距离放射治疗导管。使用校准对象得出的结论是,直径为2.25mm,最小12mm曲率半径和1.0mm开放通道的通道最适合此打印机/导管组合。根据实际患者的热塑性网状面罩的CT扫描创建模具。特定于患者的模具已通过视觉验证,可以安装在热塑性塑料网片上。结论:目视观察到的口罩适合热塑性塑料网,接下来必须将所得剂量与常规蜡模所达到的治疗计划和剂量进行比较,以验证我们的3D打印模具。

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