THE ROLE OF SRC IN STRAIN- AND LIGAND- DEPENDENT PHENOTYPIC MODULATION OF MOUSE EMBRYONIC FIBROBLASTS

摘要

Connective tissue fibrosis represents a significant portion of mortality and morbidity in our society. These diseases include many illnesses such as heart valve disease, atherosclerosis, macular degeneration, and cirrhosis, meaning that millions of lives are affected by these conditions each year. Fibrotic tissues form when quiescent fibroblasts activate becoming myofibroblasts, the phenotype of active tissue construction and fibrosis.