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Unraveling complex relationships between heterogeneous omics datasets using local principal components

机译:使用局部主成分解开异构组学数据集之间的复杂关系

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There is a growing interest in studying the dependencies between multiple data sources. A common way to analyze the relationships between a pair of data sources based on their correlation is canonical correlation analysis (CCA) which seeks for linear combinations of all variables from each dataset which maximize the correlation between them. However, in high dimensional datasets, such as genomic data, where the number of variables exceeds the number of experimental units, CCA may not lead to meaningful information. Moreover, when collinearity exists in one or both the datasets, CCA may not be applicable. In this paper, we present a novel method to extract common features from a pair of data sources using local principal components and Kendalls ranking. The results show that the proposed method outperforms CCA in many scenarios and is more robust to noisy data. Moreover, meaningful results are obtained using the proposed method when the number of variables exceeds the number of observed units.
机译:对研究多个数据源之间的依存关系的兴趣与日俱增。基于相关性分析一对数据源之间的关系的一种常用方法是规范相关分析(CCA),该方法从每个数据集中寻找所有变量的线性组合,以使它们之间的相关性最大化。但是,在高维数据集(例如基因组数据)中,变量的数量超过实验单位的数量,CCA可能不会产生有意义的信息。此外,当一个或两个数据集中都存在共线性时,CCA可能不适用。在本文中,我们提出了一种使用本地主成分和Kendalls排名从一对数据源中提取共同特征的新颖方法。结果表明,所提出的方法在许多情况下均优于CCA,并且对嘈杂的数据更具鲁棒性。此外,当变量的数量超过观察到的单位数量时,使用所提出的方法可以获得有意义的结果。

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