Evaluation of low and high molecular weight 99mTc-radiopharmaceuticals as radiotracers for thediagnosis of inflammatory process

摘要

Four 99mTc-radiopharmaceuticals (RPhs) were compared as radiotracers of inflammatoryprocess. The RPhs were divided in two groups according to their molecular weights andnature. One group included the human IgG and the ior t3 Moab (anti-CD3); another includedthe Ciprofloxacin and the DMSA. The RPhs were studied by different quality controls, andbiodistribution studies in an aseptic inflammatory model made by sterile Carrageenan and aseptic model made by E. Coli. The results obtained in the reduction of the immunoglobulins with2-mercaptoethanol and sodium metabisulphite, demonstrated that both reducing agents wereequivalent, because the radiochemical purities were similar and independent of the immunoglobulins.The biodistribution demonstrated a higher incorporation for the radiopharmaceuticals of highmolecular weight in the aseptic and septic process, and the highest values were obtained withthe 2-mercaptoethanol. The 99mTc (V)-DMSA is the only compound potentially able todiscriminate between aseptic and septic foci.