Production, Quality Control and Initial Imaging Studies of 82mRbRbInjection for PET Studies

摘要

Rubidium-82m was prepared via 15.4 MeV proton irradiation of krypton-82 gasseous target(30% enrichment, 35mCi at EOB, 6.37 mCi/μAh). The final solution was further purified using shortcolumn chromatography in order to remove organic/inorganic impurities. Radionuclidic, radiochemicaland chemical purity tests were performed prior to administration to rats (radiochemical yield: 95-97%,radiochemical purity>97%). Biodistribution studies using Rb-81 showed tracer accumulation in heart, GIand bladder. Preliminary dual-head coincidence studies were performed to determine the distribution of[82mRb]Rb in normal rats.