Ho-166 labeled DTPA Derivative for Radiation Brachytherapyusing Catheter Balloons

摘要

To develop a new liquid radiation source for the prevention of restenosis having thecharacteristic of a CT imaging on a real time basis, on site during a clinical operation, a DTPAbisamide derivative, DTPA-BTIPA (3-amino-2,4,6-triiodoisophthalic acid) was synthesized.166Ho was labeled with DTPA-BTIPA as a possible agent for IVRT for the prevention ofrestenisis. The optimum condition of the radiolabeling of DTPA-BTIPA with Ho-166 wasachieved by varying different reaction parameters. Both the radiochemical and biologicalstudies revealed that the 166Ho labeled DTPA-BTIPA can be further investigated as a potentialagent for vascular brachytherapy having the characteristic of a CT contrast. The use of the166Ho-DTPA-BTIPA for IVRT is a good alternative to see if the balloon has close contact withthe blood vessel wall for the delivery of a sufficient radiation dose to the stenotic artery.