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Influence of physicochemical parameters on drug permeation from mucoadhesive patches adhered on intestinal mucosa

机译:理化参数对粘附在肠黏膜上的黏膜黏附剂渗透的影响

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摘要

The objective of our work is to evalaute the usefulness of mucoadhesive patches for drug delivery to the mucosa of the small intestine. In the present study, various patch formulations containing different mucoadhesive polymers from the groups of carbomers and carboxy-methylcellulose sodium were tested for their drug release, mucoadhesive strength and drug permeation through excised porcine duodenal mucosa.
机译:我们工作的目的是证明粘膜粘附贴剂对药物递送至小肠粘膜的有用性。在本研究中,测试了包含来自卡波姆和羧甲基纤维素钠组的不同粘膜粘附性聚合物的各种贴剂配方的药物释放,粘膜粘附强度和通过切除的猪十二指肠粘膜的药物渗透性。

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