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Influence of physicochemical parameters on drug permeation from mucoadhesive patches adhered on intestinal mucosa

机译:物理化学参数对肠粘膜粘附粘膜药物渗透的影响

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The objective of our work is to evalaute the usefulness of mucoadhesive patches for drug delivery to the mucosa of the small intestine. In the present study, various patch formulations containing different mucoadhesive polymers from the groups of carbomers and carboxy-methylcellulose sodium were tested for their drug release, mucoadhesive strength and drug permeation through excised porcine duodenal mucosa.
机译:我们的作品的目的是评估粘膜粘附贴片对小肠粘膜的药物粘附贴片的有用性。在本研究中,通过切除的猪十二指肠粘膜测试含有不同粘液和羧基 - 甲基纤维素钠的不同粘液粘附聚合物的各种蛋白涂粘剂和羧基 - 甲基纤维素钠的蛋白质释放,粘液强度和药物渗透。

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