Improved transport of folic-acid linked peo conjugates across caco-2 monolayers

摘要

The use of cellular nutrients as covalent mediators of macromolecular and colloidal uptake is a desirable option, since receptor mediated endocytosis is a cellular process designed for transporting nutrients associated with the viability of a cell. Folate is an essential factor in purine, nucleotide, and DNA synthesis, and rapidly dividing cells express high affinities for folic acid Therefore, this pathway may be utilized to concentrate folatelinked molecules or colloids across enterocytes.