Osteoporosis is a silent disease. However, osteoporotic patients are mostly seeking for treatment until they have recognizable symptoms, such as pain or even fracture. By that time there can have been excessive bone loss. The annual rate of bone loss is generally around 1-2%, but can be as high as 3-5% in the pre- and post-menopausal period. The present study was designed to identify pre- and post-menopausal women who might be at high risk of osteoporosis defined as an annual trabecular bone loss over 3% in the non-dominate distal radius. One hundred and fifty-four randomly selected Hong Kong Chinese women aged 40 to 58 was recruited into the study. Bone mineral density (BMD) measurement on the distal radius of the non-dominant site was conducted using a highly accurate pQCT (Densiscan 2000). Two measurements were performed for each subject in a time interval of 6 months. Cortical and trabecular volumetric BMD (mg/cm/sup 3/) was calculated separately. Baseline measurements between pre- and post-menopausal women showed that the annul bone loss rate of trabecular bone (2.14%) was almost 2.5 fold faster than the cortical bone (0.86%) compared. The follow-up data from 53 subjects showed that one-third of the post-menopausal women belonged to fast bone losers. Fast bone losers were found more in low bone mass group, however without static significance. Measurements from more subjects were needed for follow-up before drawing a more reliable conclusion.
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机译:骨质疏松症是一种无声疾病。但是,骨质疏松症患者大多在寻求治疗,直到他们出现可识别的症状,例如疼痛甚至骨折。到那时,可能已经骨质流失过多。每年的骨质流失率通常在1-2%左右,但在绝经前后可能高达3-5%。本研究旨在确定可能患有骨质疏松症的绝经前和绝经后妇女,这些妇女定义为在非主要远端骨中每年小梁骨丢失超过3%。研究共招募了一百四十四名年龄在40至58岁之间的香港中国女性。使用高度精确的pQCT对非显性部位远侧radius骨的骨矿物质密度(BMD)进行测量(Densiscan 2000)。在6个月的时间间隔内对每个受试者进行两次测量。分别计算皮质和小梁的骨密度(mg / cm / sup 3 /)。绝经前和绝经后妇女之间的基线测量结果表明,与小梁骨(0.86%)相比,小梁骨的环空骨丢失率(2.14%)几乎快了2.5倍。来自53名受试者的随访数据显示,绝经后妇女中有三分之一属于快速骨质流失者。在低骨量组中发现快速骨丢失者更多,但是没有静态意义。在得出更可靠的结论之前,需要对更多受试者进行测量以进行随访。
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