Does Altered Gravity simulations Affect the Susceptibility of Lung and Vascular Cells to Anoxia-Reoxygenation Injury?

摘要

Gravitational stress will affect organ and cellular function, since gravity plays a role in ventilation and blood flow distribution, gas exchange, alveolar size and mechanical stresses within the lung. Short exposure to microgravity produced marked alterations in lung blood flow and ventilation distribution while hypergravity exaggerated the regional differences in lung structure and function resulting in reduced ventilation at the base and no ventilation of the upper half of the lung (West JB, et al., The Physiologists 25, S21, 1982). Microgravity also decreased metabolic activity in cardiac cells, WI-3u embryonic lung cells, and human lymphocytes (Cogoli A, The Physiologists 28, S47, 1985).