USE OF SMALL MOLECULE COMPOUNDS IN TREATING DISEASES MEDIATED BY LUNG EPITHELIAL CELL INJURY AND/OR VASCULAR ENDOTHELIAL CELL INJURY

摘要

Applications of 5α-androst-3β,5,6β-triol and an analog thereof, a deuterated compound thereof, or a pharmaceutically acceptable salt thereof in preparing a drug for treating a pulmonary disease of a patient. These compounds can remarkably inhibit up-regulated expression of PFKFB3, remarkably inhibit accumulation of lactic acid, remarkably reduce vascular endothelial cell injury, remarkably reduce alveolar epithelial cell injury, remarkably inhibit thickening of an alveolar septum, and remarkably reduce alveolar injury, so that these compounds can be used for treating pulmonary diseases mediated by lung epithelial cell injury and/or vascular endothelial cell injury.