OBJECTIVE To indent the function of an active ingredient from fresh pearl. METHODS Pearl extract in different concentrations were added into the 96-well plates, which contained B16 melanoma cell. The cell viability, tyrosinase activity and melanin biosynthesis of the B16 melanoma cell were measured. RESULTS The effect of pearl extract on cell viability was better than that of arbutin and alpha hydroxy acid, for example, the value of cell viability conducted by 40 mg/L pearl extract was 88.83±2.69%, similar to the 10 mg/L of arbutin and higher than that of alpha hydroxy acid with the same concentration. In terms of melanin biosynthesis, pearl extract could significantly inhibit the formation of melanin. In addition, half amount of tyrosinase could be inactived by 80mg/L pearl extract. CONCLUSION Pearl extract is of high security, and has significant whitening effect, and can be used as new whitening raw materials.
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