Glycosaminoglycans-mimicking polymers conjugated gold nanoparticles for promoting neural differentiation of embryonic stem cells

摘要

In summary, nanocomposites constructed by combining GNP with polymers containing saccharide and sulfonate units were developed to mimic the function of heparin for neural differentiation. The prepared-nanocomposites showed obvious stronger promotion effect on neural differentiation than that of natural heparin, especially the nanocomposite GNP-M1S1. The nanocomposites proposed in this work provides possible opportunities for efficient neural differentiation of ESCs.