Identifying the Cell-Cell Communication Network Driving Methacrylic Acid (MAA)-Based Biomaterial Nerve Growth

摘要

Inhibition of IGF-1 results in a decrease in the expression of peripheral nerve markers and PGP9.5 staining. These results suggest that MAA promotes axon outgrowth via IGF-1. Our research is designed to define a complex cell-cell communication network driving MAA-based peripheral nerve growth. The mechanism can be used to optimize biomaterial design which may improve therapeutic efficacy. Furthermore, MAA-based biomaterials may have applications in promoting regeneration of other injuries.