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Extent and Type of Modification of Hyaluronic Acid Influence CD44 Binding in Soluble and Hydrogel Forms

机译:透明质酸修饰的程度和类型影响可溶性和水凝胶形式的CD44结合

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Modified HA binding to CD44 is influenced by the extent and type of its modification, where increased modification (here, up to 40%) decreases binding. Thus, HA modification should be considered when designing glycomaterials for use as biomaterials. Ongoing work is evaluating the effect of modification on hMSC chondrogenesis within HA hydrogels from these same macromers and PEG hydrogel controls.
机译:修饰的HA与CD44的结合受其修饰的程度和类型的影响,其中增加的修饰(在此高达40%)降低了结合。因此,在设计用作生物材料的糖类材料时应考虑HA的修饰。正在进行的工作是评估这些相同的大分子单体和PEG水凝胶对照对HA水凝胶中hMSC软骨形成的影响。

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