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Preliminary Study of Adhesive Properties of Surface Adsorbed Human Serum Albumin and Transforming Growth Factor-β Evaluated with AFM Force Spectroscopy

机译:AFM力谱评价表面吸附人血清白蛋白和转化生长因子-β的黏附特性的初步研究

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It is a well-established fact that unbound transforming growth factor β (TGF-β) can be detected in blood plasma of Marfan syndrome patients. We use atomic force microscopy (AFM) based force spectroscopy to evaluate how adhesive properties of surface adsorbed human serum albumin (HSA) can be influenced with presence of TGF-β1. We observed that if 2% addition of TGF-β1 is present in HSA covered surfaces then measured adhesive forces never exceeded 600pN.
机译:公认的事实是,可以在马凡综合症患者的血浆中检测到未结合的转化生长因子β(TGF-β)。我们使用基于原子力显微镜(AFM)的力谱来评估TGF-β1的存在如何影响表面吸附的人血清白蛋白(HSA)的粘附特性。我们观察到,如果在HSA覆盖的表面中添加2%的TGF-β1,则测得的粘合力永远不会超过600pN。

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