Patch Film from Celullose Derivative Incorporating with Virgin Coconut Oil and its Physical and Antibacterial Properties

摘要

Preparation of mucoadhesive patch film containing Virgin Coconut Oil (VCO) has been made as a medium to inhibit the growth of Streptococcus mutans. This research was conducted to make patch film which meets the standard physical characteristic of patch mucoadhesive film. The physical characteristic is weight uniformity, thickness, folding endurance resistance, swelling index and pH of the patch solution. The presence of fatty acids which trapped in patch was analyzed with Gas Chromatography Mass Spectrometry (GC-MS). The result showed that the patch film has uniformity value of weights ranging from 0.04 to 0.17 g. The thickness of patch was 0.53 to 0.61 mm and have folding endurance resistance more than 300 times. Swelling index for each patch increase in the 5~(th) minutes and decrease in the 10th minutes. The surface pH of the patch almost close to pH 7. GC-MS chromatogram showed that lauric acid (C8), meristic acid (C14), palmitic acid (C16) and linoleic acid (C18) were trapped in the patch. The patch film containing VCO can inhibit the growth of Streptococcus mutans with inhibition zone of 157.30 ±1.088 mm~2.