Heparin/Poly-L-lysine-coated 3D-printed PLGA scaffolds as drug carriers for local immune modulation in bone regeneration

摘要

We have synthesized Hep/PLL nanoparticle-coated 3-D printed PLGA scaffold with approximately 10% NP coverage. This has implications in carrying a sufficient amount of cytokines as a drug carrier for local immune modulation in bone tissues. We also have obtained preliminary results indicating that proliferation of MC3T3-E1 mouse preosteoblast cells are adversely affected by TNF-α but not by anti-inflammatory cytokines. Our next step is to incorporate cytokines in the Hep/PLL NP system and find out the effect of local delivery.