Targeted Three-Layered Micelles and Injectable Hydrogels for Systemic and Local Gene Delivery Systems

摘要

The dual encapsulation method using electrostatic interaction and solvent condensation allowed large-sized DNA to be efficiently loaded into compact nano-sized particles using low MW low-cytotoxic PEL Furthermore, upon addition of an stereoisomeric micelle solutions to the 3LM, chain exchange between these two micelle population led to co-crystallization of PDLA/PLLA leading to network formation and eventual gelation occurred at～37°C. Biological evaluations indicated promising systemic and local delivery systems.