The combination of supramolecular and covalent chemistries enabled the formation of DN hydrogels with tunable properties, including injectability (reversible GH network) and enhanced moduli and toughness through network entanglement (covalent PEGylated fibrinogen network). The inclusion of HA and fibrinogen provide bioactive cues towards stem cell differentiation as well as enzymatic degradations. Moreover, conserving the supramolecular interaction of the GH network holds promise as means to customize DN hydrogels towards repair of visco-elastic tissues. Ongoing work is to better understand these biological interactions and utility for tissue repair.
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