Antimicrobial Activities of Conventional and Novel Antimicrobial Agents against S. aureus Biofilms

摘要

Biofilms are problematic in the pathogenesis of PJI, as they are difficult to treat and current standards of treatment, such as antibiotics and surgical techniques, may have limitations in terms of efficacy and morbidity. Therefore, there is a need for new antimicrobial agents to treat these infections. Our findings reveal that AgNPs significantly reduced the number of biofilm CFUs. The efficacy of AgNPs toward inhibiting biofilms was found to be better than some commonly used antibiotics, like vancomycin and cefazolin, at similar concentrations. Rifampin was found to be the most efficacious of all treatments applied, however rifampin may not be practical to use as it may induce antibiotic resistance and carry unwanted side effects. One limitation of the study is the composition of the biofilm in our study as they were only grown for 24 h and may not demonstrate the maturity of biofilms seen in chronic clinical infections. Future studies will be aimed at treating more established and heterogeneous biofilms in animal models.