Mineralized Collagen Matrices Increase Breast Cancer Bone Metastatic Potential

摘要

Conclusions: We have utilized a biomimetic approach to develop cell culture substrates with intrafibrillar collagen mineralization for characterizing breast cancer cell interactions with the bone ECM. Our results suggest that interactions with mineralized collagen promote breast cancer cell characteristics that may regulate their sternness and thus, clinical outcome. The substrates described herein will enable future studies to gain new insights into the role of the bone ECM in breast cancer metastasis.