Niclosamide loaded cationic Solid Lipid Nanoparticles for treatment of Cancer

摘要

Niclosamide (NIC), an anthelminthic drug exhibits poor oral bioavailability due to hydrophobic nature which limits its in vivo application. In recent times, NIC has been reported to exhibit anticancer activity against wide range of tumors. Solid Lipid Nanoparticles (SLNs) of NIC were prepared using solid lipid Glyceryl monostearate, charge modifier stearyl amine, soya lecithin, and tween 80 by emulsion solvent evaporation technique. The SLNs were characterized for their size and zeta potential using Zetasizer. Whereas, the morphology was studied using TEM analysis. The results suggested the formation of positively charged SLNs with a size range of 197.3±18.08nm and zeta potential of +10±3.43 mV. The interaction of the excipients with the drug was studied using FTIR which suggested their compatibility with NIC. The entrapment efficiency and loading efficiency was determined and found to be 75.64±8.49% and 8.16±0.31% respectively. The results of the drug release study indicated the prolonged and sustained release of NIC over a period of 24h. Hence, the NIC loaded solid lipid nanoparticles can deliver the drug for sustained period of time which can be used in the treatment of Cancer.