3d printing stereo networks microfluidic concentration gradient chip

摘要

As a new technology platform, the microfluidic concentration gradient chip (CGC) has recently attracted a large amount of interest in the field of biomedical engineering such as drug screening, chemical synthesis, trend research, cell apoptosis etc. In this work, a 4-inlet, 36-outlet stereo networks microfluidic CGC was brought forward and fabricated by 3D printing technology. Numerical simulations for the fluid flow in the network have been performed and different curves of CGC distribution can be obtained, including linear, parabola, and periodic gradients. Experiment results proved that such stereo network architectures could successfully form the desired concentration gradient and it has the merits of multiple analytes, good ductility, good readability, high-throughput, and so on, offers a unique platform to characterize various drug screening in a high-throughput fashion.