Tobramycin and Vancomycin Release from Local Delivery Devices

摘要

The release profile for the Bionova sponge shows promise in its ability to elute concentrations above MICs for vancomycin consistently over a period of time. The sponge also demonstrates the ability to release a concentration of tobramycin above the MIC at latter stages. The initial burst may lead to an inhibitory effect that is sustainable until the latter release of tobramycin. Further studies are needed to verify and validate the trends seen in this study. Equally loading all sample participants with an equivalent concentration of antibiotics should be explored to discern if the tobramycin concentration in eluates from PMMA beads are a result of the higher initial concentration or a resultant of properties delegated to PMMA.