Anisotropy Increases Myogenic Regulatory Factors and Regenerates Skeletal Muscle

摘要

In the present study, we showed that alignment had a stimulatory effect on myogenesis using myoblasts. indicating that the innate alignment of PDM could have an effect. We also showed that integrin α7 is important in myogenic differentiation and directly influences MRF protein production, and that anisotropy enhanced MRF proteins in the absence of α7. This supports its role in muscle development and disease. and suggests that α7 and alignment are necessary for stem cells to create functional muscle. Our muscle defect model provided insight into this hypothesis by demonstrating that aligned structural properties promote muscle regeneration. This study demonstrated the advantages of anisotropy in biomaterials to regenerate skeletal muscle tissue and that its use could improve the lives of those affected by traumatic muscle injuries.